You Bet Your Ass is a Canadian game show that aired on The Comedy Network. It followed a blackjack and casino motif, with contestants answering questions on popular culture to earn points. The contestant with the most points at the end of the show was the winner.

Hosted by Canadian comedian Stewart Francis and his co-host, Sitara Hewitt, the show premiered in 2005. As of June 25, 2007, the Comedy Network dropped You Bet Your Ass from its weekday lineup, replacing it with reruns of This Hour Has 22 Minutes. Reruns of You Bet Your Ass began airing in the weekday morning block on April 28, 2008 (replacing History Bites).

The series was created by Michael Geddes and Christopher Geddes of Lone Eagle Entertainment in Toronto, Ontario, Canada, who are the producers of two other game shows, Game On and Inside the Box.

The show was taped at the Canadian Broadcasting Centre in Toronto.