Toxic Crusaders is an American animated series loosely based on The Toxic Avenger films. It features Toxie, the lead character of the films, leading a group of misfit superheroes who combat pollution. This followed a trend of environmentally considerate animated series and comics of the time, including Captain Planet and the Planeteers, Swamp Thing, and Teenage Mutant Ninja Turtles Adventures, as well as animated series based on R-rated properties like RoboCop and Police Academy. As this incarnation was aimed at children, Toxic Crusaders is considerably tamer than the films it was based on, although it contained adult-oriented jokes that would go over most children's heads.

Thirteen episodes were produced and aired, with some episodes airing as a "trial run" in Summer 1990 followed by the official debut on January 21, 1991.

The show aired in Canada on YTV from 1991 to 1992. The US cable network G4 aired the first two episodes on July 25, 2009.