SOKO Rhein-Main is a German police procedural television series that premiered on 19 April 2006 on ZDF. The series aired for two seasons and was discontinued in 2008. It is the seventh offshoot of SOKO München, launched in 1978. "SOKO" is an abbreviation of the German word Sonderkommission, which means "special investigative team". The story is set in the region of Rhenish Hesse, focusing on the city of Frankfurt.

Due to differences from other shows in the SOKO franchise, the first season of SOKO Rhein-Main was titled Die Spezialisten: Kripo Rhein-Main (The Specialists: Criminal Police Rhein-Main), and the SOKO moniker was adopted in the second season and later retained for reruns.