From Hell is a 2001 American mystery horror thriller film directed by the Hughes Brothers and written by Terry Hayes and Rafael Yglesias. It is loosely based on the graphic novel of the same name by Alan Moore and Eddie Campbell about the Jack the Ripper murders. The film stars Johnny Depp as Frederick Abberline, the lead investigator of the murders, and Heather Graham as Mary Kelly, a prostitute targeted by the Ripper. Other cast members include Ian Holm, Robbie Coltrane, Ian Richardson and Jason Flemyng.

From Hell was theatrically released in the United States on October 19, 2001, by 20th Century Fox. The film grossed over $74 million worldwide and received mixed reviews from critics, with many praising the performances (particularly those of Depp and Graham), atmosphere and production values, but was negatively compared to its source material.