Destination Tokyo is a 1943 black and white American submarine war film. The film was directed by Delmer Daves in his directorial debut, and the screenplay was written by Daves and Albert Maltz, based on an original story by former submariner Steve Fisher. The film stars Cary Grant and John Garfield and features Dane Clark, Robert Hutton, and Warner Anderson, along with John Ridgely, Alan Hale Sr. and William Prince.

Destination Tokyo has been called "the granddaddy of submarine films like Run Silent, Run Deep (1958), Das Boot (1981), and U-571 (2000)".Produced during the height of World War II, the film was used as propaganda to boost morale back home and to entice young men to join the Submarine Service of the U.S. Navy.