Brian's Song is the 2001 American remake of the 1971 television film Brian's Song, telling the story of Brian Piccolo (Sean Maher), a white running back who meets, clashes with and befriends fellow Chicago Bears running back Gale Sayers (Mekhi Phifer). The movie was adapted from Sayers' own words in his 1970 autobiography, I Am Third. The television movie, produced by Columbia TriStar Television, was first broadcast in the United States on The Wonderful World of Disney on ABC on December 2, 2001.

In the movie, Piccolo is a brash rookie with the Bears. Initially thinking Sayers is arrogant – when he is only quiet and a slight bit anti-social – they rub each other the wrong way from the moment they meet. The movie, taking place from 1965 to 1970, as the civil rights movement grows, places great emphasis on integration, bringing up the conflict of when Brian and Gale room together for their first football season.