Resident Evil: The Final Chapter is a 2016 action horror film written and directed by Paul W. S. Anderson. The direct sequel to Resident Evil: Retribution (2012), it is the sixth installment in the Resident Evil film series and the final installment in the original series, which is based on the video game series of the same name. The film stars Milla Jovovich, Iain Glen, Ali Larter, Shawn Roberts, Eoin Macken, Fraser James, Ruby Rose, Rola, and William Levy. In the film, Alice and her friends are betrayed by Albert Wesker, who gathers the entire forces of the Umbrella Corporation into one final strike against the apocalypse survivors.

A sixth film in the series was announced to be in development by Sony Pictures in 2013, and Anderson later expressed his desire for it to "come full circle", bringing back characters, themes and the environment of the Hive from the first film. It was filmed in 2D and post-converted to stereoscopic 3D, and principal photography commenced on September 18, 2015 in South Africa.

Resident Evil: The Final Chapter was released on December 23, 2016, in Japan and on January 27, 2017, in the United States in 2D, 3D and IMAX 3D. The film received mixed reviews and became the highest-grossing film in the franchise, earning over $312 million worldwide against a $40 million budget. A reboot, Resident Evil: Welcome to Raccoon City, was released November 24, 2021.