The Sign of Four is a 1932 British crime film directed by Graham Cutts and starring Arthur Wontner, Ian Hunter and Graham Soutten. The film is based on Arthur Conan Doyle's second Sherlock Holmes novel The Sign of the Four (1890). The film is also known as The Sign of Four: Sherlock Holmes' Greatest Case.

It is the third film in the 1931–1937 film series starring Wontner as Sherlock Holmes.

A young woman needs Sherlock Holmes for protection when she's tormented by an escaped killer. However, when the woman is abducted, Holmes and Watson must infiltrate the city's criminal underworld to track down the young woman. It is in the public domain.