Gunfighters of Casa Grande (Spanish: Los pistoleros de Casa Grande) is a 1964 Eurowestern film, co-produced by American and Spanish producers. Based on a story by Borden and Patricia Chase, it was later developed into a screenplay with the assistance of screenwriter Clark Reynolds and directed by Roy Rowland, the last film he made for Metro-Goldwyn-Mayer.

The film starred Alex Nicol, Jorge Mistral, Dick Bentley, Steve Rowland (son of the director), Phil Posner, Mercedes Alonso, Diana Lorys, Maria Granada, Roberto Rey and Aldo Sambrell. Antonio Mayans and José Manuel Martín both had minor appearances in the film, Martin having an uncredited role.

The film's trailer was originally narrated by voice actor Don LaFontaine in his first credited role. He had been working as recording engineer and copy writer when, after the original announcer failed to appear for the scheduled recording, LaFontaine agreed to record the trailer.