Midnight Run is a 1988 American action comedy film directed by Martin Brest from a screenplay by George Gallo. It stars Robert De Niro, Charles Grodin, Yaphet Kotto, John Ashton, Dennis Farina, and Joe Pantoliano. In the film, bounty hunter Jack Walsh (De Niro) attempts to flee from New York City to Los Angeles after he captures accountant Jonathan Mardukas (Grodin), who is wanted by mob bosses and the FBI.

Midnight Run was first developed by Gallo, who then worked with Brest to revise the screenplay. De Niro was first to be cast, seeking to star in a comedy and play against type from his crime and gangster film roles during the 1970s and 1980s. Paramount Pictures were set to act as Midnight Run's distributors but backed out after casting disagreements with Brest: Universal Pictures, who distributed Brest's previous film Beverly Hills Cop (1984), then picked up the project. Principal photography took place in 1983, with filming locations including New York, Los Angeles, and across Arizona and New Zealand.

Midnight Run was theatrically released in the United States on July 20, 1988, by Universal Pictures. It grossed $81.6 million worldwide and received positive reviews from critics, with praise for its humor and the performances and chemistry between De Niro and Grodin. It was nominated for Best Motion Picture – Musical or Comedy and Best Actor (for De Niro) at the 46th Golden Globe Awards. Midnight Run inspired The Midnight Run Action Pack (1994) television film standalone sequels, which did not feature De Niro or Grodin.