Blade II is a 2002 American superhero film based on the Marvel Comics character Blade, directed by Guillermo del Toro and written by David S. Goyer. A sequel to Blade (1998), it is the second installment in the Blade franchise, followed by Blade: Trinity. The film follows the human-vampire hybrid Blade in his continuing effort to protect humans from vampires, Blade must join forces with an elite group of vampires to fight against mutant vampires who plan a global genocide of both vampire and human races.

Blade II was released in the United States on March 22, 2002, and was a box office success, grossing $155 million. It received mixed reviews from critics, earning praise for its performances, atmosphere, direction, and action sequences, although its script and character development have been criticized. The film was followed by Blade: Trinity (2004).