Blade: Trinity is a 2004 American superhero film written and directed by David S. Goyer. It was produced by Goyer, Peter Frankfurt, Lynn Harris, and Wesley Snipes, who also starred in the leading role as the title character. Based on the Marvel Comics character of the same name, it is the third installment in the Blade trilogy, and co-stars Ryan Reynolds, Jessica Biel, Kris Kristofferson, Dominic Purcell, Parker Posey, and Triple H. Vampire leader Danica Talos has framed Blade for numerous murders, and alongside a team of rogue vampire hunters he must fight his most challenging enemy yet, Dracula.

Blade: Trinity was released in the United States on December 8, 2004. The film grossed $132 million at the box office worldwide on a budget of $65 million and received mostly negative reviews from critics for its formulaic themes, directing, and acting; it is the worst-reviewed film in the trilogy. The film was followed by a television series, Blade: The Series, in 2006, with Sticky Fingaz replacing Snipes. Marvel regained the film rights to the character in 2012. Snipes reprised his role as Blade in the 2024 film Deadpool & Wolverine, which starred Reynolds as Deadpool. A reboot film set in the Marvel Cinematic Universe and starring Mahershala Ali is in development.