Ma Barker's Killer Brood is a 1960 American neo noir crime film, released in 1960. The low-budget film was directed by Bill Karn and starred Lurene Tuttle as the title character, Ma Barker.

The film is a highly fictionalized account of the life of Ma Barker and her four sons, whose Barker-Karpis gang terrorized the South and Midwest in the 1930s with a string of kidnappings, robberies, and murders. The gang members are also depicted working with other well-known criminals of the era, including John Dillinger (Eric Sinclair), and Baby Face Nelson (Robert Kendall).