Curious George is a 2006 animated adventure film based on the book series written by H. A. Rey and Margret Rey. It was directed by Matthew O'Callaghan (in his theatrical feature directorial debut), written by Ken Kaufman and produced by Ron Howard, David Kirschner, and Jon Shapiro. Featuring the voices of Frank Welker, Will Ferrell, Drew Barrymore, David Cross, Eugene Levy, Joan Plowright, and Dick Van Dyke, it tells the story of how the Man with the Yellow Hat, a tour guide at a museum, first befriended a curious monkey named George and started going on adventures with him around the city while attempting to save the museum from closure.

It is the first theatrically-released animated film from Universal Pictures since 1995's Balto, the first theatrical animated film from Universal Animation Studios (making this Universal's first in-house theatrical animated film), and the first animated film from Imagine Entertainment. The film had languished in development hell at Imagine Entertainment since at least 1992, but it is possible that it was conceived years before. The film employs a notable blend of traditional animation and computer-animated scenery and objects that make up 20% of its environment. The soundtrack was composed by Heitor Pereira and features several songs by musician Jack Johnson.

Curious George was released in the United States by Universal Pictures on February 10, 2006. It was met with generally positive reviews, but was a box-office failure, grossing only $70 million worldwide against a budget of $50 million. Curious George made $48 million in DVD sales in the home market. It got several direct-to-video sequels after release.