Johnny Mnemonic is a 1995 cyberpunk action film directed by Robert Longo in his feature directorial debut. William Gibson, who wrote the 1981 short story, wrote the screenplay. The film, set in 2021, portrays a dystopian future racked by a tech-induced plague, awash with conspiracies, and dominated by megacorporations and organized crime. Keanu Reeves plays Johnny, a data courier with an overloaded brain implant designed to securely store confidential information. Takeshi Kitano portrays a yakuza affiliated with a megacorporation attempting to suppress the data; he uses his in-house psychopathic assassin played by Denis Akiyama to do so. Ice-T and Dina Meyer co-star as Johnny's allies, a freedom fighter and a bodyguard, respectively.

It was shot in Canada; Toronto and Montreal filled in for Newark and Beijing. The project was difficult for Gibson and Longo. After they struggled for years to finance a low-budget adaptation of Gibson's story, Sony greenlit Johnny Mnemonic with a $26 million budget. When Reeves' previous film, Speed, unexpectedly became a major hit, Sony attempted to retool Johnny Mnemonic as a blockbuster. Longo experienced extensive creative differences with the studio, who forced casting choices and script rewrites on him. The film was ultimately recut without Longo's involvement, resulting in a version that he felt did not reflect his artistic vision. Described by Longo and Gibson as originally full of irony, it was edited into a mainstream action film and received negative reviews from critics.

A longer version (103 mins) of the film premiered in Japan on April 15, 1995, featuring a score by Mychael Danna and more scenes involving Kitano. The film was released in the United States on May 26, 1995. In 2022, a black-and-white edition of the film, titled Johnny Mnemonic: In Black and White was released, which Gibson characterized as closer to his original vision.