Wise Blood is a 1979 black comedy drama film directed by John Huston and starring Brad Dourif, Dan Shor, Amy Wright, Harry Dean Stanton, and Ned Beatty. It is based on the 1952 novel Wise Blood by Flannery O'Connor. As a co-production with Germany the film was titled Der Ketzer or Die Weisheit des Blutes when released in Germany, and Le Malin when released in France.

The film follows the lives of a war veteran preacher and his associates. When he refuses to pose as a prophet for a promoter, the promoter convinces a replacement to copy the preacher's manner of dressing and style of preaching. The preacher eventually blinds himself and becomes unresponsive to his environment. His landlady has an unrequited love for him. She continues trying to revive him, even when he is seemingly dead.