Quarantine is a 2008 found footage horror film directed and co-written by John Erick Dowdle, produced by Sergio Aguero, Doug Davison, and Roy Lee, and co-written by Drew Dowdle, being a remake of the 2007 Spanish film Rec. The film stars Jennifer Carpenter, Jay Hernandez, Columbus Short, Greg Germann, Steve Harris, Dania Ramirez, Rade Šerbedžija, and Johnathon Schaech. It follows a reporter and her cameraman assigned to a pair of Los Angeles firemen who follow a distress call to an apartment building where they discover a deadly mutated strain of rabies spreading among the building's occupants; escape becomes impossible once the government descends upon the building to prevent the virus from spreading beyond it, and the pair continue to record the events that unfold inside, of which the film itself is the result. Quarantine features no actual musical score, using only sound effects, and differs in its characters, dialogue, and explanation of the virus from its source material.

Quarantine was released in the United States by Sony's subsidiary Screen Gems on October 10, 2008. The film received mixed reviews from critics and grossed $41.3 million worldwide at the box office. It was followed by a sequel, Quarantine 2: Terminal (2011).