How to Murder Your Wife is a 1965 American black comedy film from United Artists, produced by George Axelrod, directed by Richard Quine, that stars Jack Lemmon and Virna Lisi. Quine also directed Lemmon in My Sister Eileen, It Happened to Jane, Operation Mad Ball, The Notorious Landlady and Bell, Book and Candle. The film was co-produced by Lemmon's company, Jalem Productions, and Axelrod's company Charleston Enterprises, through a one-shot holding company, Murder, Inc.

The comic strip art featured in the film was credited to Mel Keefer, who drew newspaper comic strips such as Perry Mason, Mac Divot and Rick O'Shay. Comics artist Alex Toth did a teaser comic strip in Keefer's style that ran in The Hollywood Reporter and in several newspapers promoting the film for ten days prior to its theatrical opening.