The Saint Takes Over, released in 1940 by RKO Pictures, was the fifth of eight films in RKO's film series about Simon Templar, also known as "The Saint", the Robin Hood-inspired crimefighter created by Leslie Charteris. George Sanders played Templar for the fourth time. Sanders made one more Saint picture the following year. Wendy Barrie played his latest romantic interest, in her second of three appearances in the Saint film series (playing a different character each time).

In 1941, RKO replaced its "Saint" series with The Falcon, also starring George Sanders.