Detective vs Sleuths is a 2022 Hong Kong action thriller film directed, co-written and co-produced by Wai Ka-fai, starring Sean Lau, Charlene Choi, Raymond Lam and Carman Lee. The film follows a former police with a mental disorder (Lau), who works with an elite inspector (Choi) in a series of murders which are seemingly connected to past cases they've once inspected. They find themselves in a race against time to find out the truth and the mastermind behind these murders.

Originally announced in 2018, the film marks Wai's return to direct since the 2009 film Written By, and a reunion with frequent collaborator Sean Lau. Filming took place in Hong Kong and Guangzhou from 21 August 2018 to 17 December 2018, and the film entered the post-production process in April 2019.

Detective vs Sleuths was released in Hong Kong on 21 July 2022, after a postponed period due to COVID closure of Hong Kong and China theatres. The film has received critical acclaim and was won 4 of total 11 categories at the 41st Hong Kong Film Awards, including Best Director for Wai Ka-fai, Best Screenplay, Best Actor for Sean Lau and Best Cinematography, and also nominated for Best Film.