Charlotte's Web is a 2006 fantasy film based on the 1952 novel by E. B. White. Directed by Gary Winick and written by Susannah Grant and Karey Kirkpatrick, it is the third and final film of Paramount's Charlotte's Web franchise, and the second film adaptation of E. B. White's book after the 1973 animated feature film produced by Hanna-Barbera Productions. The film stars Dakota Fanning, Kevin Anderson, and Beau Bridges, with voices provided by Dominic Scott Kay, Julia Roberts, Steve Buscemi, John Cleese, Oprah Winfrey, Thomas Haden Church, André Benjamin, Cedric the Entertainer, Kathy Bates, Reba McEntire, Robert Redford, and Sam Shepard as the narrator. Danny Elfman composed the film's score.

Produced by Walden Media, Jordan Kerner's The K Entertainment Company and Nickelodeon Movies, the film premiered in Australia on December 7, 2006 and was released theatrically by Paramount Pictures on December 15, 2006 in the United States. The film received mostly positive reviews from critics, yet was only modestly commercially successful. It grossed $83 million at the US box office and $61 million elsewhere for a worldwide total of $144 million against an $85 million budget, as well as grossing an additional $95.2 million in home media sales.

A video game of the same name was derived from the movie.