Alpha and Omega is a 2010 American animated adventure film directed by Anthony Bell and Ben Gluck. Starring the voices of Justin Long, Hayden Panettiere, Dennis Hopper, Danny Glover and Christina Ricci, the film was written by Christopher Denk and Steve Moore, based on a story by Moore and Gluck. This film sets around two young Rocky Mountain wolves named Kate (Panettiere) and Humphrey (Long) who fall in love with each other, but are on the opposite ends of their pack. However, when Kate and Humphrey learn that they got relocated to Idaho for repopulation, they must work together to get back to Jasper National Park before a war slowly begins to emerge between both packs.

The film premiered at the Toronto International Film Festival on September 8, 2010, and was released nationwide in 2-D and 3-D on September 17, 2010, by Lionsgate Films. Alpha and Omega was a box-office success, grossing $50.5 million against a budget of $20 million, but received generally negative reviews from critics, who lamented its screenplay, plot and animation, though the voice acting and Bacon's musical score received praise. The film was dedicated to the memory of Hopper, as he died from prostate cancer four months before it was released. This was his final performance prior to his death.

The film eventually turned into a franchise of 7 direct-to-video sequels including Alpha and Omega 2: A Howl-iday Adventure, which was released on October 8, 2013. Another sequel, The Great Wolf Games, was released on March 25, 2014. The Legend of the Saw Tooth Cave was released on September 23, 2014. Family Vacation was released to DVD on August 4, 2015. Dino Digs was released on DVD and Digital HD on May 10, 2016. It was followed by The Big Fur-eeze, which was released on November 8, 2016. The final installment, Journey To Bear Kingdom was released on DVD and Digital HD on May 9, 2017.