Poison Ivy is a 1992 American erotic thriller film directed by Katt Shea. It stars Drew Barrymore, Sara Gilbert, Tom Skerritt and Cheryl Ladd. The original music score is composed by David Michael Frank. The film was shot in Los Angeles.

It premiered at Sundance on January 21, 1992, where it was nominated for the Grand Jury prize of Best Film. Although it did not fare very well at the box office, grossing $1,829,804 with its limited theatrical release to 20 movie theaters, the film received favorable word-of-mouth, and became a success on cable and video in the mid-1990s. It has since gained status as a cult film, and is the first installment in a Poison Ivy film series that includes three direct-to-video sequels.