The Human Centipede 3 (Final Sequence) is a 2015 black comedy body horror film written and directed by Tom Six and starring Dieter Laser and Laurence R. Harvey, the leading actors from the first two films in new roles, Robert LaSardo, Tommy "Tiny" Lister, Jay Tavare, Eric Roberts, Bree Olson, Clayton Rohner, and Bill Hutchens as well as a cameo by Six. The film tells the story of a psychopathic prison warden and his accountant who create their own "human centipede" from the inmates. It is the conclusion to Six's The Human Centipede trilogy.

The Human Centipede 3 was released both theatrically and on video on demand on 22 May 2015. The film was panned by critics due to its overwhelming gore and repetitive plot to its predecessors. It was deemed one of the worst films of 2015 and at the Golden Raspberry Awards, it was nominated for Worst Prequel, Remake, Rip-off or Sequel and Six was nominated for Worst Director.