Life According to Sam is an HBO original documentary film directed by Sean Fine and Andrea Nix Fine. Premiering in January 2013 at the Sundance Film Festival, the documentary discloses the impact that progeria had on the lives of Sam Berns and his parents, Dr. Leslie Gordon and Dr. Scott Berns. It was broadcast on HBO in October 2013, and since then it has won a 2013 Peabody Award and an Emmy Award for Exceptional Merit in Documentary Filmmaking. It was also one of the 15 titles considered for nomination in the Documentary Feature category for the 86th Oscars.

Told from the personal point of view of Sam, his parents, and other families suffering from the effects of progeria, the documentary raises awareness on this currently incurable disease. It informs and educates the audience on what progeria is, what it means for patients, and calls attention to the need for research on treatment.