The Mind of Mark DeFriest (also known as The Life and Mind of Mark DeFriest) is a documentary film about Mark DeFriest, a man imprisoned by the State of Florida since 1980, who spent 27 of those years in solitary confinement. His original four-year sentence, for taking his father's tools after his death, before they had been released to him by the court, and then fleeing the police, has been repeatedly extended due to numerous escape attempts, seven of which were successful, and because of infractions committed while in prison.

"If I was a rapist or a murderer, they'd let me out," DeFriest says in the film. "But I'm the idiot who made them look like idiots."