The 2010 Money in the Bank was the inaugural Money in the Bank professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on Sunday, July 18, 2010, at the Sprint Center in Kansas City, Missouri. The event included two Money in the Bank ladder matches, one for each brand. The eponymous ladder match was previously held at WrestleMania from 2005 to 2010. Following WrestleMania XXVI in March, the match concept was spun off into its own PPV event, replacing Night of Champions, which had moved to September replacing Breaking Point. The event received 169,000 pay-per-view buys.

Eight matches were contested at the event, including the two Money in the Bank ladder matches. The Miz won Raw's ladder match to earn a WWE Championship match at a time of his choosing within the next year, while in the opening bout, Kane won SmackDown's ladder match for the same opportunity for the World Championship. In the main event, Sheamus retained the WWE Championship against John Cena in a Steel Cage match, following an interference from The Nexus. The undercard featured The Hart Dynasty (David Hart Smith and Tyson Kidd) retaining the Unified WWE Tag Team Championship against The Usos (Jey Uso and Jimmy Uso) and Layla retaining the WWE Women's Championship against Kelly Kelly. Also on the card, Rey Mysterio defeated Jack Swagger to retain the World Championship, only to lose it minutes later to Kane, who cashed in the Money in the Bank contract he won earlier in the event to defeat Mysterio for the title.