Desert of Blood is a 2008 independent film about a vampire, Luis Diego, who has been left imprisoned underground by the village priest. When accidentally released, he begins to exact revenge on the villagers. However, when he falls in love with a young woman who is visiting the village to care for her aging aunt, he must face the possibility of forgiveness. The story is set in modern-day Mexico.

This film features a largely Latino cast, and was filmed in the Mexican town of Tecate.