Mr. Moto Takes a Chance is the fourth in a series of eight films starring Peter Lorre as Mr. Moto, although it was the second one actually filmed, following Think Fast, Mr. Moto. Its release was delayed until after production of Thank You, Mr. Moto and Mr Moto's Gamble.

The film is based on the character of Mr. Moto created by John P. Marquand, and an original story by Norman Foster and Willis Cooper.