The 2006 Lockdown was a professional wrestling pay-per-view (PPV) event produced by Total Nonstop Action Wrestling (TNA), which took place on April 23, 2006, at the Impact Zone in Orlando, Florida. It was the second annual event under the Lockdown chronology. Eight matches were featured on the event's card. In the concept of Lockdown events, every match took place inside a steel structure with six sides, known as Six Sides of Steel. This event also marked the TNA debut of Christy Hemme. The event was featured in the House episode "Act Your Age".

In October 2017, with the launch of the Global Wrestling Network, the event became available to stream on demand.