Blue in the Face is a 1995 American comedy film directed by Wayne Wang and Paul Auster. It stars Harvey Keitel leading an ensemble cast, including Giancarlo Esposito, Roseanne Barr, Michael J. Fox, Lily Tomlin, Victor Argo, Mira Sorvino, Lou Reed, Keith David, Jim Jarmusch, Jared Harris, RuPaul, and Madonna.

Blue in the Face was filmed over a five-day period as a follow-up to Wang's 1995 film Smoke. During production of Smoke, Keitel and the others ad-libbed scenes in-character between takes and a sequel was made using this improvised material.

Lily Tomlin was nominated for an American Comedy Award as "Funniest Supporting Actress in a Motion Picture" for her performance in this picture.

Blue in the Face features songs by singer Selena. Her bilingual duet with David Byrne, "God's Child (Baila Conmigo)", appears on the film's soundtrack.