Safe is a 1995 American psychological drama film written and directed by Todd Haynes and starring Julianne Moore. Set in 1987, it follows a suburban housewife in Los Angeles whose monotonous life is abruptly changed when she becomes sick with a mysterious illness which she believes is caused by the environment around her.

The film topped the "best film of the 1990s" poll by The Village Voice, and was described by critics as "the scariest film of the year", "a mesmerizing horror movie", and "a work of feminist counter-cinema". Twenty years after the film's release, Haynes said its themes—disease and immunity in a post-industrial landscape and how recovery is a burden often placed on victims of illness—were even more relevant than they were when the film was released.