The Cape Town Affair is a 1967 South African spy film directed and produced by Robert D. Webb, written by Dwight Taylor, produced by the 20th Century Fox at Killarney Film Studios in South Africa. The film stars Claire Trevor, James Brolin, and Jacqueline Bisset. It is a remake of the 1953 picture Pickup on South Street.

It was Brolin's first starring role. Both he and Bisset were under contract to Fox. He later said "I didn't like it much but we [he and Bisset] weren't bad."