Earth vs. the Spider is a 2001 science fiction horror television film directed by Scott Ziehl. It is the second of a series of films made for Cinemax paying tribute to the films of American International Pictures. The films in this tribute series reused the titles of old American International Pictures films, in this case the 1958 Bert I. Gordon film Earth vs. the Spider, but are not remakes of the earlier films. The film centers on a shy, obsessive comic book fan who gets injected with an experimental serum derived from spiders, which gives him minor superpowers. More horrific changes occur, slowly transforming him into a grotesque human spider hybrid. A detective begins to investigate when bodies start to pile up covered in cobwebs. The film was nominated for the Saturn Award at the Academy of Science Fiction, Fantasy, and Horror Films, USA.