The Notorious Lone Wolf is a 1946 American mystery film directed by D. Ross Lederman and starring Gerald Mohr, Janis Carter and Eric Blore. It is the twelfth Lone Wolf film produced by Columbia Pictures. The picture features Mohr in his inaugural performance as the protagonist detective Lone Wolf alongside Janis Carter and Ian Wolfe as Adam Wainwright, the film's antagonist. The screenplay was written by Martin Berkeley, Edward Dein, and William J. Bowers.

The film centres on former jewel looter Michael Lanyard, also known by his alias "Lone Wolf", aiming to clear his name after he is accused of murdering a bar dancer. At the same time, he races to retrieve a stolen piece of jewellery. Filming took place in October and November 1945. The Notorious Lone Wolf was theatrically released in the United States in February 1946. It was followed by The Lone Wolf in Mexico, in 1947.