The Boy in the Plastic Bubble is a 1976 American made for television drama film inspired by the lives of David Vetter and Ted DeVita, who lacked effective immune systems. It stars John Travolta, Glynnis O'Connor, Diana Hyland, Robert Reed, Ralph Bellamy and P.J. Soles. It was written by Douglas Day Stewart, produced by Aaron Spelling and Leonard Goldberg (who, at the time, produced Starsky and Hutch and Charlie's Angels), and directed by Randal Kleiser, who would work with Travolta again in the 1978 hit musical film adaptation of Grease shortly after. The original music score was composed by Mark Snow. The theme song "What Would They Say" was written and sung by Paul Williams. William Howard Taft High School was used for filming.

The TV movie first aired November 12, 1976 on ABC. In the United Kingdom, the TV movie was released on PAL DVD by Prism Leisure in 2001 before it finally made its terrestrial television debut on Channel 5 in 2006.