Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip is an upcoming American family road comedy film directed by Marvin Lemus from a screenplay written by Matt Lopez. It is a standalone sequel to the 2014 film Alexander and the Terrible, Horrible, No Good, Very Bad Day, which was based on the book of the same name by Judith Viorst. It stars Eva Longoria, Jesse Garcia, Paulina Chávez, Rose Portillo, Thom Nemer, and Cheech Marin.

In December 2020, Disney hired writer Matt Lopez to pen a follow-up to Alexander and the Terrible, Horrible, No Good, Very Bad Day for Disney+. The sequel will follow a similar plot, but will instead focus on a "multigenerational Latino family". 21 Laps Entertainment and The Jim Henson Company are also set to return. In October 2022, Marvin Lemus signed on to direct while Eva Longoria was cast as Alexander's mother. The new film features the family going on a road trip. By March 2024, the film's title was changed to Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip.

The film will be released exclusively on Disney+ on March 28, 2025.