Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip is a 2025 American family road comedy film directed by Marvin Lemus and written by Matt Lopez. It is a standalone sequel to the 2014 film Alexander and the Terrible, Horrible, No Good, Very Bad Day, which was based on the children's book of the same name by Judith Viorst. It stars Eva Longoria, Jesse Garcia, Paulina Chávez, Rose Portillo, Thom Nemer, and Cheech Marin.

In December 2020, Disney hired Lopez to write a follow-up to Alexander and the Terrible, Horrible, No Good, Very Bad Day for Disney+. It follows a similar plot, but focuses on a "multigenerational Latino family". 21 Laps Entertainment and The Jim Henson Company returned to produce the film. In October 2022, Marvin Lemus signed on to direct while Eva Longoria was cast as Val. It features the family going on a road trip. By March 2024, the title was changed to Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip.

The film was released exclusively on Disney+ on March 28, 2025.