Orphan: First Kill is a 2022 American psychological horror film directed by William Brent Bell and written by David Coggeshall, based on a story by David Leslie Johnson-McGoldrick and Alex Mace. A prequel to Orphan (2009), it stars Isabelle Fuhrman reprising her role as the titular character, with Julia Stiles, Rossif Sutherland, Hiro Kanagawa, and Matthew Finlan in supporting roles.

With the working title of Esther, the project was announced in February 2020. The official title was revealed in November that same year, with Fuhrman reprising her role as Esther. Filming took place in Winnipeg, Canada, from November to December 2020.

Orphan: First Kill premiered first in other territories starting in the Philippines on July 27, 2022, and was released in the United States on August 19, by Paramount Pictures through the Paramount Players label in select theatres, digital, and streaming via Paramount+. The film grossed $44 million worldwide and received mixed reviews from critics.