Mexican Spitfire is a 1940 American comedy film starring Lupe Vélez. She plays a hot-headed, fast-talking Mexican singer taken to New York for a radio gig, who decides she wants the ad agency man for herself. The film was the sequel of the film The Girl from Mexico (1939) and was the first of a film series of seven more films with the same title and main characters.

A sneak preview of the film in December 1939 prompted RKO to order three more in the series.