Cobra is a 2022 Indian Tamil-language psychological action thriller film directed by R. Ajay Gnanamuthu and produced by 7 Screen Studio. The film stars Vikram in dual roles, alongside Srinidhi Shetty, Irfan Pathan, Roshan Mathew, Sarjano Khalid, Mirnalini Ravi, Miya George, K. S. Ravikumar, Anandaraj, Robo Shankar and Meenakshi Govindarajan. It marked the acting debut of Irfan Pathan, previously a cricketer, and the Tamil debuts of Roshan Mathew, Sarjano Khalid and Srinidhi Shetty. In the film, an Interpol officer is assigned to catch a mysterious assassin, who intelligently assassinates people using mathematical skills, named "Cobra".

The project was officially announced in May 2019, under the tentative title Vikram 58 as it is the actor's 58th film as a lead actor, and the official title was announced that December. Principal photography commenced in October 2019 and nearly took three years due to the impact of the COVID-19 pandemic on cinema, travel restrictions and Vikram's commitments on other projects, wrapping only in February 2022. It was primarily shot in Chennai, while filming also took place in Kerala, Kolkata and Russia. The film has music composed by A. R. Rahman, cinematography handled by Harish Kannan and editing by John Abraham and Bhuvan Srinivasan.

Cobra was released worldwide on 31 August 2022 in theatres, coinciding with Vinayaka Chathurthi, got generally negative reviews from critics, who praised Vikram's performance, Rahman's music, the cinematography and concept but criticized its convoluted screenwriting and excessive length. The film was a box-office bomb.