Madagascar: Escape 2 Africa (also known as Madagascar 2: Escape to Africa) is a 2008 American animated adventure comedy film produced by DreamWorks Animation SKG and PDI/DreamWorks and distributed by Paramount Pictures. The second in the Madagascar film series, it was directed by Eric Darnell and Tom McGrath and written by Etan Cohen, Darnell, and McGrath. The film features Ben Stiller, Chris Rock, David Schwimmer, Jada Pinkett Smith, Sacha Baron Cohen, Cedric the Entertainer, Andy Richter, Elisa Gabrielli, McGrath, Chris Miller, Christopher Knights, and Conrad Vernon reprising their voice acting roles from the first film, joined by new cast members Bernie Mac, Alec Baldwin, Sherri Shepherd, and will.i.am, as well as voice acting veteran John DiMaggio. In the film, the main characters, a party of animals from the Central Park Zoo whose adventures have taken them to Madagascar find themselves in the African savannas, where they meet others of their species and where Alex the lion reunites with his parents.

The film, like its predecessor, has a score composed by Hans Zimmer. Singer will.i.am contributed five songs to the soundtrack.

Released on November 7, 2008, Madagascar: Escape 2 Africa received generally positive reviews from critics for its characters, humor and animation, with critics considering it an improvement over its predecessor, and grossed $603.9 million on a $150 million budget, making it the sixth highest-grossing film of 2008. It was dedicated to Bernie Mac, who died on August 9, 2008 before the film's release. A sequel, Madagascar 3: Europe's Most Wanted, was released in June 2012.