Megamind is a 2010 American animated superhero comedy film produced by DreamWorks Animation and Pacific Data Images, and distributed by Paramount Pictures. Directed by Tom McGrath from a screenplay by Alan Schoolcraft and Brent Simons, the film stars the voices of Will Ferrell, Tina Fey, Jonah Hill, David Cross, and Brad Pitt. It tells the story of Megamind, a highly intelligent alien supervillain; after defeating his long-time nemesis Metro Man, Megamind creates a new hero to fight but must act to save the city when his "creation" becomes an even worse villain than he was.

Megamind premiered in Russia on October 28, 2010, and was released in the United States on November 5. It garnered generally positive reviews from critics and it grossed $321.9 million worldwide on a $130 million budget. In the years following its release, the film gained a cult following via a variety of Internet memes.

It later spawned a franchise, including three console video games and a short film titled Megamind: The Button of Doom, which was released with the film's DVD and Blu-ray on February 25, 2011. A sequel film, Megamind vs. the Doom Syndicate, and follow-up series, Megamind Rules!, premiered on Peacock on March 1, 2024.