The Venture Bros.: Radiant Is the Blood of the Baboon Heart is a 2023 American direct-to-video adult animated science fiction action adventure film based on the Adult Swim animated series The Venture Bros., where it serves as the series finale. The film is directed and co-written by the series creator Jackson Publick and writer Doc Hammer, who serves as the film's executive producers and features the voices of the show's returning principal cast, James Urbaniak, Patrick Warburton, Michael Sinterniklaas, Publick and Hammer. The film centers on a nationwide manhunt for Hank Venture, which leads to a coming darkness from the past that involves the Venture Family, the Guild, and the Monarch themselves.

Originally envisioned as a potential eighth season of the series, the film is the second of Adult Swim's line of direct-to-video movies after Aqua Teen Forever: Plantasm, and was released by Warner Bros. Home Entertainment on digital on July 21, 2023, and Blu-ray on July 25, 2023, followed by its availability on Max (known during the film's production as HBO Max) 90 days later.