Anna Karenina is a 1935 Metro-Goldwyn-Mayer film adaptation of the 1877 novel Anna Karenina by Leo Tolstoy and directed by Clarence Brown. The film stars Greta Garbo, Fredric March, Basil Rathbone, and Maureen O'Sullivan. There are several other film adaptations of the novel.

In New York, the film opened at the Capitol Theatre, the site of many prestigious MGM premieres. The film earned $2,304,000 at the box office, and won the Mussolini Cup for best foreign film at the Venice Film Festival. Greta Garbo received a New York Film Critics Circle Award for Best Actress for her role as Anna. In addition, the film was ranked #42 on the American Film Institute's list of AFI's 100 Years...100 Passions.