Karthikeya 2 is a 2022 Indian Telugu-language mystery adventure film written and directed by Chandoo Mondeti. A sequel to the 2014 film Karthikeya, it stars Nikhil Siddhartha and Anupama Parameswaran. The film is produced by Abhishek Agarwal Arts and People Media Factory. In the film, Dr. Karthikeya is on a quest to find the lost anklet of Lord Krishna.

The film was officially launched in March 2020. Filming took place in India, predominantly in Gujarat and Himachal Pradesh, in addition to Spain, Portugal, and Greece in Europe from February 2021 to March 2022. Made on a budget of ₹15 crore, Karthikeya 2 was released on 13 August 2022 to positive reviews from critics and emerged as a sleeper hit, in both Telugu and Hindi, becoming the 6th highest-grossing Telugu films of 2022. It won the Best Feature Film in Telugu at the 70th National Film Awards.