The Case Against Mrs. Ames is a 1936 American mystery drama film written by C. Graham Baker and Gene Towne based on a serial of the same name by Arthur Somers Roche originally published in Collier's Weekly magazine in 1934, and then as a novel in 1936. The film was directed by William A. Seiter and stars Madeleine Carroll and George Brent, and features Arthur Treacher, Alan Baxter, Beulah Bondi and Alan Mowbray.