Dr. Jerkyl's Hide is a 1954 Warner Bros. Looney Tunes monster movie directed by Friz Freleng. The short was released on May 8, 1954, and stars Sylvester.It is the first of three cartoons that Friz Freleng made based on Robert Louis Stevenson's 1886 novella Strange Case of Dr Jekyll and Mr Hyde, the others are Hyde and Hare (1955) and Hyde and Go Tweet (1960). This is the final appearance of the antagonistic canine duo Spike the Bulldog and Chester the Terrier (although Spike is named "Alfie" in this short) from the golden age of American animation; speaking with a British accent throughout.

This cartoon's plot follows the same formula as Tree for Two (1952), except that this time it is a Dr. Jekyll and Mr. Hyde parody, as opposed to a black panther that escaped from the zoo. Sylvester is trying to escape a pair of British dogs (Alfie the Bulldog and Chester the Terrier). He accidentally ingests Dr. Jekyll's formula (thinking it is soda pop), causing him to become a monster named Mr. Hyde and terrorizes Alfie and causes Chester to call Alfie a coward.