Scream VI is a 2023 American slasher film directed by Matt Bettinelli-Olpin and Tyler Gillett, and written by James Vanderbilt and Guy Busick. It is the sequel to Scream (2022) and the sixth installment in the Scream film series. The film stars Melissa Barrera, Jenna Ortega, Jasmin Savoy Brown, Mason Gooding, Hayden Panettiere, and Courteney Cox, all reprising their roles from previous installments, with Josh Segarra, Jack Champion, Devyn Nekoda, Liana Liberato, Tony Revolori, Samara Weaving, Henry Czerny, and Dermot Mulroney joining the ensemble cast. The plot follows a new Ghostface killer, who begins targeting the survivors of the "Woodsboro legacy murders" in New York City.

A sixth Scream film was announced just weeks after the successful debut of Scream (2022), with much of the cast signing on to reprise their roles alongside Bettinelli-Olpin and Gillett's return. Filming took place in Montreal, Canada, from June to late August 2022. Neve Campbell did not reprise her role as Sidney Prescott due to a pay dispute, making this the first Scream film not to feature her. Brian Tyler composed the film's score, with Sven Faulconer co-scoring.

Scream VI premiered at the AMC Lincoln Square Theater in Manhattan on March 6, 2023, and was theatrically released in the United States on March 10 by Paramount Pictures. The film received generally positive reviews from critics and grossed $169 million worldwide, becoming the first installment in the franchise to earn over $100 million at the domestic US box office since Scream 2 (1997) and the highest-grossing Scream film in the United States and Canada (unadjusted for inflation). It won Best Movie at the 2023 MTV Awards. A sequel is in development.