Scream is a 2022 American slasher film directed by Matt Bettinelli-Olpin and Tyler Gillett, and written by James Vanderbilt and Guy Busick. It is a sequel to Scream 4 (2011), the fifth installment in the Scream film series, and the first in the series not directed by Wes Craven, who died in 2015 and to whom the film is dedicated. It is also the first film in the franchise not to be produced by Dimension Films due to it becoming defunct in 2019, and the first film to be distributed by Paramount Pictures. The film stars Melissa Barrera, Kyle Gallner, Mason Gooding, Mikey Madison, Dylan Minnette, Jenna Ortega, Jack Quaid, Jasmin Savoy Brown, and Sonia Ammar, with Marley Shelton, Skeet Ulrich, Roger L. Jackson, Heather Matarazzo, Courteney Cox, David Arquette, and Neve Campbell reprising their roles from previous installments. The plot takes place twenty-five years after the original Woodsboro murders from Scream (1996), when yet another Ghostface appears and begins targeting a group of teenagers who are each somehow linked to the original killings.

Although fifth and sixth Scream installments were discussed after the release of Scream 4 in 2011, Craven, writer Kevin Williamson, and executive producer Harvey Weinstein had doubts about proceeding with more films following the less-than-expected box office performance of the fourth film. After the 2017 sexual assault allegations against Weinstein and the closure of the Weinstein Company, the rights to the Scream franchise were obtained by Spyglass Media Group in November 2019, who confirmed a new film would later be made. The following year, Williamson, who was returning as an executive producer, confirmed the film would not be a reboot and that Bettinelli-Olpin and Gillett had been hired in March 2020 to direct the film. Campbell and Arquette were confirmed to be returning later that month, with Cox and the new cast members joining throughout the middle of the year. Filming took place between September and November 2020 in North Carolina. To avoid any plot leaks, numerous versions of the screenplay were produced, and several additional scenes were filmed. Brian Tyler, a frequent collaborator of Bettinelli-Olpin and Gillett, was hired to compose and conduct the film's score, replacing Marco Beltrami, the composer of the previous four films.

Scream was released in the United States on January 14, 2022, by Paramount Pictures. The film received generally positive reviews from critics, who praised the direction, performances and tribute to Craven, with some calling it the best Scream sequel. It was also a box-office success, grossing over $138 million against a production budget of $24 million. A sequel, Scream VI, was released on March 10, 2023.