Mission: Impossible 2 (titled onscreen as Mission: Impossible II and abbreviated as M:I-2) is a 2000 action spy film directed by John Woo, and produced by and starring Tom Cruise. It is the sequel to Mission: Impossible (1996) and the second installment in the Mission: Impossible film series. The film also stars Dougray Scott, Thandiwe Newton, Richard Roxburgh, John Polson, Brendan Gleeson, Rade Šerbedžija and Ving Rhames. In the film, Ethan Hunt (Cruise) teams with professional thief Nyah Nordoff-Hall (Newton) to secure a genetically modified disease, Chimera, held by rogue Impossible Missions Force (IMF) agent Sean Ambrose (Scott), who is Nordoff-Hall's former lover.

Mission: Impossible 2 was theatrically released in the United States by Paramount Pictures on May 24, 2000, and grossed $546 million worldwide, becoming the highest-grossing film of that year. Initial reactions from critics were mixed, with praise for the action sequences and Woo's direction, but criticism for the characterization. A sequel, Mission: Impossible III, was released in 2006.